BioScience Trends. 2015;9(5):280-283. (DOI: 10.5582/bst.2015.01131)

Associating liver partition and portal vein ligation (ALPPS): Taking a view of trails.

Takamoto T, Sugawara Y, Hashimoto T, Makuuchi M


Associating liver partition and portal vein ligation (ALPPS) is introduced as a modified twostaged hepatectomy for advanced liver malignancies, which requires extended hepatectomy with very small future remnant liver volume. It is characterized by rapid and large growth of future remnant liver and potential of widening the indication of curative resection with extended major hepatectomy for liver malignancies. It showed, however, much higher morbidity and mortality than extended hepatectomy after portal vein embolization. Here, we review the literatures and examine the role of ALPPS in Japan, where zero mortality after hepatectomy is highly expected.

KEYWORDS: ALPPS, Japan, hepatectomy, liver malignancies, liver volume, portal vein embolization

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