BioScience Trends. 2013;7(1):42-49. (DOI: 10.5582/bst.2013.v7.1.42)

Prognostic significance of β-catenin expression in patients with non-small cell lung cancer: A meta-analysis.

Mei XD, Su H, Song J, Dong L


β-Catenin has been reported to play a crucial role in the invasion and metastasis of lung cancer. However, the value of β-catenin as a prognostic factor for non-small cell lung cancer (NSCLC) remains controversial. The present study systematically reviewed the evidence of predicting significance of β-catenin expression in NSCLC patients with meta-analysis. Twelve literatures were included by searching PubMed, Cochrane library, and EMBASE databases. Separate hazard ratio estimates and a 95% confidence interval (CI) for the prognostic value of β-catenin in NSCLC were extracted and merged from the included literatures. The summary hazard ratios were 1.91 (95% CI 1.60-2.28), indicating a worse overall survival for NSCLC patients with reduced β-catenin expression. There was no significant heterogeneity among the studies (X2 = 12.41, p = 0.413, I2 = 3.3%). Publication bias was not statistically significant. Sensitivity analysis showed that omission of any single study had little effect on the combined risk estimates. This meta-study revealed that decreased β-catenin expression denoted a poor prognosis in NSCLC patients.

KEYWORDS: β-Catenin, non-small cell lung cancer, prognosis, overall survival

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