BioScience Trends. 2026;20(1):14-26. (DOI: 10.5582/bst.2026.01002)

Implications of mitochondrial function in embryonic development

Wang J, Zhou J, Wang YY, Li Y, Wang L, Li LS

Mitochondria are organelles that play a crucial role in various physiological processes. They are particularly important during embryonic development, as their proper function is required for essential processes such as fertilization, implantation, and embryonic growth. In addition to their well-known role in adenosine triphosphate (ATP) synthesis and energy production, mitochondria serve multiple other functions during embryonic development. These include the synthesis of important metabolites, involvement in cell signaling pathways, regulation of reactive oxygen species, and facilitation of interactions between organelles. The mitochondrial genome, known as mitochondrial DNA (mtDNA), also plays a unique role in embryonic development. Dysfunction in mitochondria can lead to failures in fertilization, suboptimal embryo development, post-implantation failures, and mitochondrial-related diseases in adults. Advances in sequencing technology and experimental techniques have greatly improved our understanding of mitochondrial function. This paper reviews the roles of mitochondrial functions in embryonic development and the influence of mitochondrial technologies and it highlights the potential impact of understanding mitochondria's unique genetic and functional characteristics on embryonic development and offspring health.

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