BioScience Trends. 2022;16(5):367-370. (DOI: 10.5582/bst.2022.01331)

A brief summary regarding the roles of interleukin-11 in neurological diseases

Airapetov M, Eresko S, Ignatova P, Lebedev A, Bychkov E, Shabanov P


Interleukin 11 (IL-11) was discovered in 1990 in fibrocyte-like stromal cells of the bone marrow, but there has recently been an increased interest in the cytokine. Understanding the physiological roles of cytokines will allow their use as pharmacological agents in clinical practice. Studies have indicated that IL-11 affects the mechanism for the development of a number of pathologies of the nervous system. IL-11 plays a significant role in the central nervous system. The local expression of this cytokine by nerve cells has been observed. The current work summarizes the results of studies which found that the cytokine affects the mechanism of development of pathologies of the central nervous system. In the near future, this cytokine may be used clinically to fix the mechanisms that are involved in the development of pathological conditions of the nervous system.

KEYWORDS: IL-11, IL-6 family, gp130, brain, neuroinflammation, neurodegeneration

Full Text: